Effects of the antihypertensive drug benidipine on osteoblast function in vitro

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Effects of the antihypertensive drug benidipine on osteoblast function in vitro

The dihydropyridine-type calcium channel blocker, benidipine (BD) has been widely used in hypertension therapy. Previous studies have demonstrated that BD has a positive effect on bone metabolism. Inspired by this promoting phenomenon, the present study investigated the effects of BD on osteoblasts in vitro. Experiments were designed and performed, including an MTT assay, reverse transcription-...

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Several studies have suggested that high blood pressure is associated with the risk of bone loss. Since various antihypertensive drugs are in wide use for the treatment of hypertension, it is important to investigate the influences of these drugs on bone metabolism. Osteoblasts play a pivotal role in the regulation of bone formation. During differentiation, they sequentially express type I coll...

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ژورنال

عنوان ژورنال: Experimental and Therapeutic Medicine

سال: 2014

ISSN: 1792-0981,1792-1015

DOI: 10.3892/etm.2014.1475